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PB-22 and 5F-PB-22 check here were being the initial synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are believed to are synthesized with the intention of creating a synthetic cannabinoid prodrug, which could boost absorption and confound detection. Ester bonds are simply biodegradable through spontaneous or endogenous, nonspecific esterase hydrolysis, which has been frequently Employed in medicinal chemistry to create ester prodrugs.

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